Oxycodone and acetaminophen tablets are for oral use only. Abuse of oxycodone and acetaminophen tablets poses a danger of overdose and death. The danger is amplified with concurrent abuse of oxycodone and acetaminophen tablets with Liquor as well as other central anxious system depressants.

The developmental and overall health great things about breastfeeding should be thought of combined with the mom’s scientific want for PERCOCET and any opportunity adverse effects within the breastfed toddler from PERCOCET or from your fundamental maternal condition.

Adrenal insufficiency: Situations of adrenal insufficiency have been claimed with opioid use, more usually next higher than a person thirty day period of use.

Using PERCOCET will not be suggested for patients using MAOIs or inside 14 times of halting this kind of treatment.

Lifetime-Threatening Respiratory Despair Notify clients of the potential risk of lifetime-threatening respiratory melancholy, which include data that the chance is best when beginning PERCOCET or in the event the dosage is elevated, Which it may possibly take place even at proposed dosages.

Extended use of opioid analgesics during pregnancy for healthcare or nonmedical purposes may end up in physical dependence from the neonate and neonatal opioid withdrawal syndrome shortly just after delivery.

Take into consideration prescribing naloxone, according to the client’s hazard variables for overdose, such as concomitant utilization of CNS depressants, a history of opioid use problem, or prior opioid overdose.

For the duration of pregnancy, website this medication need to be utilised only when Obviously essential. It could harm an unborn child. Examine the risks and Rewards with the medical doctor.

Haven't furnished sufficient analgesia, or usually are not envisioned to provide enough analgesia CONTRAINDICATIONS

Concomitant use of oxycodone and acetaminophen tablets with CYP3A4 inducers or discontinuation of an CYP3A4 inhibitor could reduce oxycodone plasma concentrations, lower opioid efficacy or, perhaps, cause a withdrawal syndrome inside a affected person who had formulated Actual physical dependence to oxycodone.

Respiratory melancholy would be the chief danger for elderly people taken care of with opioids, and it has happened immediately after big Original doses were being administered to individuals who weren't opioid-tolerant or when opioids were co-administered with other agents that depress respiration.

Monitor patients for possibility of compound use Diseases, which includes opioid abuse and misuse, and alert them of the danger for overdose and death connected with the use of more CNS depressants which includes alcohol and illicit prescription drugs.

The mix of oxycodone and acetaminophen hasn't been evaluated for mutagenicity. Oxycodone on your own was adverse within a bacterial reverse mutation assay (Ames), an in vitro chromosome aberration assay with human lymphocytes without having metabolic activation, and an in vivo mouse micronucleus assay.

Observe newborns for signs of neonatal opioid withdrawal syndrome and take care of appropriately. Recommend pregnant Women of all ages employing opioids for an prolonged time frame of the chance of neonatal opioid withdrawal syndrome and be sure that correct treatment are going to be available [see Safety measures; Information for Clients/Caregivers, Pregnancy].